Anaphylaxis Research Today is a free monthly online journal that collates and summarizes the latest research about Anaphylaxis, including details on food allergies, diagnosis, treatment, causes.

Biphasic anaphylaxis: review of incidence, clinical predictors, and observation recommendations.

Tole JW, Lieberman P

Department of Internal Medicine, University of Tennessee Health Science Center, 842 Jefferson Avenue, Suite A601, Memphis, TN 38103, USA. jtole@utmem.edu

Biphasic anaphylactic reactions have been found to develop in as many as 20% of anaphylactic reactions. The biphasic reaction can be less severe, equally severe, or more severe than the initial reaction, ranging in degree from mild symptoms to fatal reactions. In this review, retrospective and prospective studies as well as case studies and case series are discussed in an attempt to gain insight on the incidence of biphasic reactions, the potential clinical characteristics suggestive of a uniphasic reaction developing into a biphasic reaction, and the recommendations for observation periods after an anaphylactic reaction.

Published 11 May 2007 in Immunol Allergy Clin North Am, 27(2): 309-26, viii.
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