Anaphylaxis Research Today is a free monthly online journal that collates and summarizes the latest research about Anaphylaxis, including details on food allergies, diagnosis, treatment, causes.

Anaphylactic reaction to different gonadotropin-releasing hormone agonists for the treatment of endometriosis.

Lüchinger AB, Mijatovic V, Rustemeyer T, Hompes PG

Department of Reproductive Medicine, Endometriosis Center, VU University Medical Center, Amsterdam, The Netherlands.

Anaphylactic reactions to gonadotropin-releasing hormone (GnRH) agonists are exceedingly rare, but if they occur, they can be life threatening. This case describes a 33-year-old patient with endometriosis who developed an acute allergic reaction on leuprolide (Lucrin) administration. Although skin tests with the replacement goserelin (Zoladex) were negative, usage of this medication resulted in a similar allergic reaction. This is the first case report that shows that, in case of a proven allergy to one GnRH agonist, a switch to another GnRH agonist should not be made even if allergy tests are negative for this medication.

Published 23 February 2011 in Am J Med Sci, 341(3): 240-2.
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Articles on Anaphylaxis published 24 January 2011:

Incidence of immediate gadolinium contrast media reactions.   AJR Am J Roentgenol, 196(2): W138-43.

[Abstract] [Full-text]

Articles on Anaphylaxis published 17 January 2011:

Age-related differences in the clinical presentation of food-induced anaphylaxis.   J Pediatr, 158(2): 326-8.

Food-induced anaphylaxis may be more difficult to recognize in younger children. We describe age-related patterns in the clinical presentation of children with anaphylaxis, which may facilitate the early recognition and treatment of this potentially life-threatening condition. [Abstract] [Full-text]

Articles on Anaphylaxis published 14 January 2011:

Sugammadex in the management of rocuronium-induced anaphylaxis.   Br J Anaesth, 106(2): 199-201.

Anaphylaxis during anaesthesia is a rare event that in ∼60-70% of cases is secondary to neuromuscular blocking agents. It has been suggested previously that the recent introduction of sugammadex may provide a novel therapeutic approach to the management of rocuronium-induced anaphylaxis. We describe the case of a 33-yr-old female who suffered a severe anaphylactic reaction to rocuronium, presenting with cardiovascular collapse on induction of anaesthesia. After 19 min of traditional ... [Abstract] [Full-text]

Sugammadex in the management of rocuronium-induced anaphylaxis.   Br J Anaesth, 106(2): 199-201.

Anaphylaxis during anaesthesia is a rare event that in ∼60-70% of cases is secondary to neuromuscular blocking agents. It has been suggested previously that the recent introduction of sugammadex may provide a novel therapeutic approach to the management of rocuronium-induced anaphylaxis. We describe the case of a 33-yr-old female who suffered a severe anaphylactic reaction to rocuronium, presenting with cardiovascular collapse on induction of anaesthesia. After 19 min of traditional ... [Abstract] [Full-text]

Articles on Anaphylaxis published 11 January 2011:

Anaphylactic shock to fresh-frozen plasma inactivated with methylene blue.   Transfusion, 51(1): 125-8.

[Abstract] [Full-text]

Articles on Anaphylaxis published 27 October 2010:

Anaphylactic reaction owing to ondansetron administration in a child with neuroblastoma and safe use of granisetron: a case report.   J Pediatr Hematol Oncol, 32(8): e341-2.

A 1-year-old girl with stage-IV neuroblastoma developed ondansetron hydrochloride anaphylaxis. Safe use of granisetron as an antiemetic after skin prick, oral, and intravenous challenge tests is presented. We present this case to emphasize that ondansetron hydrochloride may cause a serious anaphylactic reaction. In such a case, granisetron may be given to patients as an antiemetic after some provocative tests performed. [Abstract] [Full-text]

Articles on Anaphylaxis published 14 September 2010:

Use of parenteral iron products and serious anaphylactic-type reactions.   Am J Hematol, 85(9): 650-4.

Controversy exists about the safety of the parenteral iron dextran products, Dexferrum and INFeD, which have been associated with rare, serious anaphylactic-type reactions. In the United States, their product labels carry boxed warnings of this adverse event; some have called for the withdrawal from marketing of the higher molecular weight Dexferrum. Between 2002 and 2007, sales of Dexferrum, INFeD, and iron gluconate Ferrlecit declined 32.5%, 21%, and 4.8%, respectively, while sales of iron ... [Abstract] [Full-text]

Articles on Anaphylaxis published 6 September 2010:

The diagnosis and management of anaphylaxis practice parameter: 2010 update.   J Allergy Clin Immunol, 126(3): 477-80.e1-42.

These parameters were developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology (AAAAI); the American College of Allergy, Asthma & Immunology (ACAAI); and the Joint Council of Allergy, Asthma and Immunology. The AAAAI and the ACAAI have jointly accepted responsibility for establishing "The Diagnosis and Management of Anaphylaxis Practice Parameter: 2010 Update." This is a complete and comprehensive document at ... [Abstract] [Full-text]

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